Supporting Technologies & Capabilities

Imaging

RxGen applies a range of medical imaging modalities in support of primate drug discovery and development studies.

  • SPECT
  • X-Ray
  • Dual energy X-ray absorptiometry (DEXA)
  • Ultrasound
  • Behavioral and neuromotor video
  • Other

Behavioral and Neuromotor Assessment

  • Behavioral scoring
    • Healthy behavior
    • Parkinsonian behavior
    • Adverse drug reaction
  • Memory and cognitive testing
    • Spatial working memory
    • Long-term recognition memory
    • Attentional and executive functions
    • Sensorimotor gating
    • Motivation
    • Fine motor skills
  • Gait analysis
    • Treadmill training and kinematics

Analytics

RxGen conducts and coordinates multiple endpoint analyses to support study execution.

  • ELISA
  • Expression analysis
  • Necropsy and histopathology
  • Anatomic characterization
  • Tissue culture
  • High performance liquid chromatography
  • Mass spectroscopy
  • Clinical pathology
    • Clinical chemistry
    • Hematology
    • Coagulation profiles
    • Other peripheral markers
  • Glucose Tolerance Test (GTT)
  • Minimally invasive biopsies
  • Telemetry

Ophthalmic Testing and Evaluation

  • Refraction
  • Anterior segment exam and photography
  • Gonioscopy
  • Direct and indirect retinoscopy
  • Fundus photography and fluorescein angiography
  • A and B scan ultrasonography
  • Electroretinography
  • Anatomic and histologic assessment
  • Retinal and trabecular laser

Scientific Consultation

  • Development of integrated protocols for preclinical assessment of efficacy and/or safety
  • Staged study designs for evaluation of feasibility and ultimate realization of program objectives

Quality Assurance and Regulatory Support

  • AAALAC Accredited Test Facility
  • Good Laboratory Practice (GLP)
    • Facility infrastructure and standard operating procedures are compliant with GLP requirements
  • Quality Assurance (QA)
    • QA auditing of GLP safety studies
    • Internal QAO and independent consultant
  • Institutional Animal Care and Use Committee (IACUC)
    • Independent but responsive IACUC evaluates all animal use protocols abiding by best practices and the reduce, refine, replace maxim of animal testing
    • AAALAC accredited test facilities
  • Investigational New Drug (IND) Applications
    • Support of animal pharmacology and toxicology component of sponsor-initiated IND filings